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AND: Use to combine two or more variables; AND narrows your search:
substance abuse AND short-term therapy
OR: Use when searching for synonymous or closely-related terms; OR broadens your search:
substance abuse or drug abuse or alcoholism or drug addition or . . .
* :The asterisk (shift/8 on the keyword) is the truncation symbol used in most databases. It's a quick shorthand for singular, plural, noun and adjectival forms of words. For examples, addict* looks for: addict, addicts, addiction, addictions, addictive, etc.